Research Associate in Immunology

Infection, Immunity and Respiratory Medicine, University of Manchester, UK

You will work on a project that aims to unravel a novel mechanism in the control of memory T cell function during viral re-infection. It is based on exciting results from our preliminary studies, which show that a subset of CD4+ memory T cells selectively express an integrin, αvβ8, which allows them to activate the cytokine TGF-β. These cells appear to suppress CD8+ T cell function and clearance of a respiratory viral pathogen.

The project aims to characterise the cellular and molecular mechanisms underlying this new paradigm, identify its functional importance in host immune defence using murine models, and its role in regulating responses to viral re-infection in humans. The results will provide a step-change in our understanding of how memory T cell responses are controlled during viral infection, and reveal candidate mechanisms that could be targeted to promote more effective responses to infection.

Essential requirements/skills for the post include:

• Holding (or expect to hold shortly) a PhD or equivalent in Immunology or a related Biological Science
• Extensive up-to-date theoretical and practical knowledge in immunology-focussed laboratory research
• Excellent technical skills in murine models used to study the immune system
• Extensive experience in flow cytometry

Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies.

Enquiries about the vacancy, shortlisting and interviews:

• Professor Mark Travis