|Institution:||Queen Mary University of London (QMUL)|
|Salary:||£33,615 - £44,015|
|Line 1:||Queen Mary University of London|
Applications are sought for a Postdoctoral Research Assistant to work on the role of iRhom2 in the immune-epidermal cell stress response. We have previously identified dominantly-inherited point mutations in the gene encoding iRhom2 (RHBDF2) to be associated with an inherited syndrome of a hyperproliferative skin condition (palmoplantar keratoderma) and oesophageal squamous cell carcinoma (OMIM:148500). Since then we have shown iRhom2 to have key functions in the keratinocyte cell stress response including regulation of ADAM17, the cytoskeleton and p63 signalling (Maruthappu et al Nature Communications 2017; Arcidiacono et al Nature Communications 2018).
This full-time position is funded by the Medical Research Council for 36 months to work on elucidating the genetic and cellular pathways regulated by iRhom2 in the keratinocyte/immune stress response in both human tissue and established in vivo model systems. The project will have a particular focus on hyperproliferative keratinocyte disorders including the skin disease psoriasis and also squamous cancer. The position will have the support of a research assistant also funded by the MRC.
The post will be based in the group of Professor David Kelsell in the Centre for Cell Biology and Cutaneous Research, Blizard Institute, within the Barts and the London School of Medicine and Dentistry, Queen Mary University of London. The Blizard Institute is an outstanding research environment with excellent core facilities including microscopy and flow-cytometry. Barts and The London School of Medicine was ranked 7th in the UK for research in Clinical Medicine in the most recent Research Excellence Framework (REF) 2014.
Applicants for this Postdoctoral Research Assistant post are expected to have a PhD with experience in epithelial and/or immune biology and signaling/pathway analysis. Salary will be in the range of £41,682 - £44,015 inclusive of London Allowance. Benefits include 30 days annual leave, pension scheme and interest-free season ticket loan.
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.