|Institution:||Barts Cancer Institute|
|Salary:||£33,615 ¿ £39,483|
|Line 1:||Barts Cancer Institute|
Applications are sought for a Postdoctoral Research Assistant to undertake research investigations in collaboration with and under the supervision of the Principal Investigator (PI) in order to realise the objectives and development of the research programme. The research will be based in the Centre for Molecular Oncology, Barts Cancer Institute, within the Barts and The London School of Medicine and Dentistry, Queen Mary University of London.
Essential requirements for this post include a PhD in a relevant biological subject and an undergraduate degree in a biological subject. Significant research laboratory experience in cell and molecular biology is essential. Experience in the field of cancer immunology and virology as well as in bioinformatics would be an advantage. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential.
The research is aimed at identifying drugs that enhance virus replication, promoting cell lysis leading to the activation of the host anticancer immune-responses. The focus is pancreatic ductal adenocarcinoma (PDAC), a cancer of unmet clinical need that is poorly immunogenic, surrounded by a dense impenetrable stroma that prevent access of immune factors and therapeutic drugs. Our recently developed oncolytic adenovirus Ad5-3Δ-A20T specifically targets PDAC and stromal cells (Man et al, MCT 2018). In this project, we will identify drugs that further increase adenoviral spread and cell killing in the tumour microenvironment to boost anti-tumour immune responses by maximizing exposure of tumour-associated antigens to the host immune system. Annotated small molecule libraries will be screened using 3D spheroid organoid co-cultures of PDAC cells and cancer-associated fibroblasts (CAFs) for improved cell killing. Selected gene target hits will be validated by CRISPR/Cas 9 and the compound hits by in vitro and in vivo immune assays.
The post is funded by Pancreatic Cancer Research Fund (PCRF) for 3 years full time starting as soon as possible.
Candidates must be able to demonstrate their eligibility to work in the UK in accordance with the Immigration, Asylum and Nationality Act 2006. Where required this may include entry clearance or continued leave to remain under the Points Based Immigration Scheme.
Informal enquiries about this post, including arrangements to visit the Institute/Centre, can be made to Dr Gunnel Halldén, Tel: +44 2078823593
Details about Barts Cancer Institute can be found at www.bci.qmul.ac.uk