Research Associate in Malignant Blood Stem Biology

Job Details
Closing Date: 2019-08-06
Institution: University of York
Keyword Names: Academic/Research, Cancer/Oncology
Salary: £32,236 - £39,609
Address
Line 1: University of York
City: York
Country: United Kingdom

Job Description

Research Associate in Malignant Blood Stem Biology

University of York, York, UK

Role Description

We are looking for a highly qualified full-time Postdoctoral Research Associate to join the group of Dr David Kent based in the Department of Biology at the University of York.

The Kent laboratory's research focuses on understanding cell fate decisions in normal and malignant blood stem cells. We have recently pioneered approaches in single cell biology which link single stem cell function to single cell gene expression (Wilson et al, Cell Stem Cell; Nestorowa et al., Blood; Shepherd et al., Blood 2018) and determined that the order of mutation acquisition impacts disease evolution and clinical features of blood cancers (Ortmann et al., NEJM).

The position will explore malignant stem cells with Tet2 mutations to understand disease evolution and stem cell expansion. As the successful candidate, you will join an existing project studying the role of Tet2 in mouse and human blood stem cells. You will drive an independent project but also work closely with other lab members. You will also assist in the identification and development of potential areas of research and the development of proposals for independent or collaborative research projects as well as write up research results for dissemination through publications, seminar and conference presentations and public engagement and outreach activities. Opportunities for mentorship and additional collaborations will be available and encouraged.

The successful candidate must hold a PhD or equivalent research experience in mouse stem cell biology with specific expertise in single stem isolation and culture, mouse models, bone marrow transplantation and macrophage biology. Additional knowledge of stem cells from other tissues and flow cytometry would be advantageous. They must have prior research experience involving blood stem cells and in using mouse models. Experience of studying Tet2 and inflammation would be particularly advantageous. They will have demonstrable research experience and will have presented their research at international conferences.

This position is funded by ERC.

Informal enquiries are welcomed and should be made to Dr. David Kent via email: david.kent@york.ac.uk.  For an alternative contact, please email biol-dmthub@york.ac.uk.