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Wet Lab Postdoctoral Research Associate

Job Details
Closing Date: 2021-07-05
Institution: The Francis Crick Institute
Term: 2 years
Keyword Names: Academic/Research, Cancer/Oncology, Postdoctoral
Address
Line 1: The Francis Crick Institute
Line 2: King's College London
City: London
Country: United Kingdom

Job Description

Wet Lab Postdoctoral Research Associate

Comprehensive Cancer Centre, The Francis Crick Institute, King's College London, UK

KCL seeks an independent and motivated Postdoctoral Research Associate with a strong background in cellular and molecular cancer immunology and an interest in understanding the interplay between cancer of the gastrointestinal tract and the host immune cells.

We are a multidisciplinary team devoted to cancer research and we combine computational and wet-lab approaches. The successful candidate will be leading on the wet-lab component of research projects in the field of cancer immunogenomics.

Exemplar techniques used in the group include bulk, spatial and single cell genomics and transcriptomics as well as high dimensional imaging of cancer tissues, such as solid cyTOF or multiplexed immunofluorescence. Moreover genetic manipulations of primary or established cancer cell lines for hypothesis validation and mechanistic insights are also frequently used.

A day-by-day interaction with computational biologists in the lab and clinical and immunology collaborators will ensure a dynamic and stimulating scientific environment.
The lab is part of the School of Cancer & Pharmaceutical Sciences of King's College London and are located at The Francis Crick Institute in London (see here). The candidate will have full access to top-class experimental facilities at King's College London, Crick and Cancer Research UK City of London Centre.

Informal inquiries can be addressed at francesca.ciccarelli@crick.ac.uk

Contract Type

This post will be offered on a fixed-term contract for 2 years. This is a full-time post - 100% full time equivalent.

Key responsibilities

  • Lead on the experimental component of multidisciplinary research project
  • Work synergistically with computational colleagues in the team
  • Collaborate actively with partner labs to exchange data and results
  • Present data and results internally and externally in a timely and organised manner

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

  1. PhD awarded or near completion in Molecular biology, Immunology, Cancer Biology or equivalent
  2. Background in cancer immunology
  3. Technical expertise in standard basic molecular and cellular techniques
  4. Experience with DNA/RNA extraction and NGS library prep from clinical samples (including FFPE)
  5. Technical expertise in high dimensional immunostaining
  6. Excellent research ability and strong communication skills (both speaking and writing)

Desirable criteria

  1. Prior experience with cyTOF and imaging cyTOF
  2. Prior experience with working with clinical samples

*Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

This post is subject to Occupational Health clearance.

Applications can be made here.