Higher Scientific Officer in Target Validation & Immuno Oncology Drug Discovery

Job Details
Closing Date: 2019-08-01
Institution: The Institute of Cancer Research
Term: 3 years
Keyword Names: Academic/Research, Cancer/Oncology
Salary: £33,285 - £41,437
Line 1: The Institute of Cancer Research
City: Sutton
Country: United Kingdom

Job Description

Higher Scientific Officer in Target Validation & Immuno Oncology Drug Discovery

The Institute of Cancer Research, Sutton, UK

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer. Vacancy Description  

CRUK CTU now seeks to appoint a Higher Scientific Officer in Target validation & Immuno Oncology Drug Discovery. This position is for three years in the first instance. Reporting to the Unit Director Professor Raj Chopra and Team Leader, the particular focus of the successful appointee will be on progression of innovative small molecule anticancer compounds to proof-of-concept clinical trials. The skills that are desirable but not essential as training will be given include;

  • Ability to undertake tissue culture including culture of immune cells
  • Multi-colour flow cytometry to explore the immune-spectrum within tissues
  • Protein biochemistry including immunoprecipitation and western blotting
  • Molecular biology techniques such as molecular cloning, PCR and RNA CRISPR knock down assays.

This position is critical for strengthening our emerging Immuno Oncology drug discovery portfolio within the Cancer Therapeutics Unit and will work closely with a multi-disciplinary group of scientists. The current project is exploring ways to modulate MHC-I antigen presentation in order to re-engage the immune system within the tumour microenvironment.

You will be joining a high performing team with team science at the core of our values. This position will also offer training in new techniques and support will be available for attending training courses and appropriate academic meetings.

Job Description and Person Specification:  HSO - Job Description.pdf