PhD students | ‘Ganglioside-containing liposomes as a strategy for cancer vaccination’

Job Details
Closing Date: 2019-03-28
Institution: Amsterdam University Medical Centre
Keyword Names: PhD / Graduate Studentship, Cancer/Oncology, Academic/Research
Salary: 2357 to 3020 euro
Address
Line 1: Amsterdam UMC
City: Amsterdam
Country: Netherlands

Job Description

2 PhD students | ‘Ganglioside-containing liposomes as a strategy for cancer vaccination’

A joint PhD challenge in immunological and pharmaceutical research

Amsterdam University Medical Centre, Amsterdam, The Netherlands

Your challenge

The PhD students will formulate different types of liposomes, study the binding and uptake by different immune cells in vitro and in vivo and will determine the activation of immune responses by these liposomes. The project involves testing human in vitro models and in vivo mouse models with the ultimate goal to translate our findings to the clinic.
The two candidates will be working either at the Amsterdam UMC (location VUmc) or the UU in an international, multidisciplinary team with young and enthusiastic researchers. The project is a joint research program between the group of Dr. Joke den Haan (department of Molecular Cell Biology and Immunology at Amsterdam UMC location VUmc) and the group of Prof. dr. Gert Storm (department of Pharmaceutics, UU). One PhD candidate will work at the VUmc location and the other will work at the UU location. Both candidates will very closely interact in order to generate liposome-based vaccines that can be applied as a vaccination to treat cancer.

As a PhD student your main tasks and responsibilities are:

  • To formulate and characterize different types of liposomes containing tumor antigens and/or adjuvants;
  • To determine the binding and uptake of liposomes by human and mouse immune cells;
  • To investigate the liposomes for their capacity to activate the complement system;
  • To determine the activity of liposomes to activate anti-cancer immune responses in mouse models;
  • To complete your research with a PhD thesis and degree.

Your profile

We are looking for two highly motivated and enthusiastic researchers with:

  • A master degree in Pharmaceutical and/or Biomedical Sciences, with affinity for Immunology;
  • Experience with cellular responses, liposomes, and preferably animals (article 9);
  • You have a flexible, pro-active team spirit but you can also work independently;
  • You have excellent communications skills in English, both written and verbal.

Your work environment

Research within the departments Molecular Cell Biology and Immunology (VUmc) and Pharmaceutics (UU) is performed in a stimulating environment and at an international high competitive level. The focus is on nanomedicines and immunology. The group of Joke den Haan investigates the functions of macrophages and dendritic cells in the immune system and aims to develop cancer vaccines that target tumor antigens to these cells. The research group of Prof. dr. Gert Storm develops new nanomedicines for the treatment of several types of diseases. You will be working in team with young and enthusiastic researchers.

We offer

Salary Scale PHD: 2357 tot 3020 euro gross when employed full-time (depending on qualifications and experience).

In addition we offer:
– Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay.
– Your pension premium will be paid by us for 2/3.
– We reimburse 75% of your OV travel costs.

For more information about our employment conditions, please visit our website.

Additional information

The PhD positions are each for four years and are supported through a ZonMw TOP grant. The intended start date for the project is July 1st 2019. We first offer a fixed term contract for 1 year, which under normal circumstances will be prolonged with 3 years.