|Institution:||Beatson Institute for Cancer Research|
|Salary:||£31,604 to £41,929|
|Line 1:||Beatson Institute for Cancer Research|
Dr Ed Roberts
We are building a new group focussed on understanding how anti-tumour immune responses are initiated in the lymph node (LN). We are interested in how the LN microenvironment is informed by signals from the periphery and how this influences downstream T cell outcomes. T cells stimulated within the tumour draining LN differentiate in a suboptimal manner and we seek to understand why and whether this can be manipulated to improve the quality and/or quantity of anti-tumour immunity.
One major focus of our group is dendritic cells (DC) since these are incompletely activated in the tumour draining LN and these have the capacity to differentially skew anti-tumour T cells. Using in vivo models of both infection and cancer we seek to understand the channels of communication between the peripheral tissue and the lymph node to better understand how these can be manipulated to improve anti-tumour immunity. Ultimately we hope to investigate whether these interventions may synergise with existing immunotherapeutic approaches.
Applicants must have a PhD in a relevant field and be driven by scientific curiosity. Existing skills with regard to mammalian cell culture and flow cytometry along with experience of immunology and in vivo cancer models will be an advantage.
To find out more about this unique opportunity to establish advanced skills and expertise in the exciting field of tumour immunology please contact Dr. Ed Roberts