|Institution:||University of York|
|Salary:||£32,817 - £40,322|
|Line 1:||University of York|
Immunology is a primary research focus within the York Biomedical Research Institute. Our work aims to reveal the molecular mechanisms underpinning immunity and immunopathology during complex infectious and non-communicable inflammatory diseases. In this context, leishmaniasis is a globally important parasitic disease with over 1M new cases each year across 98 countries. The York Biomedical Research Institute boasts one of the largest groups of researchers working on leishmaniasis in academia, with partnerships in >20 countries. Our work on leishmaniasis spans the whole spectrum from mechanistic immunology, parasite biology to human challenge and vaccination trials. This immunology post is funded by a MRC-FAPESP Joint Centre Partnership award between the University of York and the University of Sao Paulo and is funded for two years.
We are seeking to appoint a postdoctoral scientist with a strong interest in mechanistic immunology to carry out research on the microenvironmental control of myeloid cell function, using single-cell transcriptomics and multiplex spatial profiling (e.g. GeoMx Digital Spatial Profiling). You will have the opportunity to work in multidisciplinary team. You will conduct an independent research project using tissue samples derived from clinical cohorts in endemic countries and from animal models of infection, whilst also working with a larger team. You will analyse and interpret research data to address timely questions in myeloid biology and identify future research directions. You will write up research results, and disseminate them through publications, lab meetings, seminar and conference presentations and public engagement activities.
Skills, Experience & Qualification needed
You will have a PhD in immunology or a related discipline and an interest in discovering molecular mechanisms driving immunity to infection. You will have knowledge of myeloid cell biology including research around heterogeneity and its relationship to function. You will have research expertise in cellular and or molecular immunology, specialist IT knowledge, knowledge of flow cytometry, imaging and or immunohistochemistry and a broad understanding of immunology / immunity to infectious disease. Knowledge of single cell profiling technologies and pipelines is desirable but not essential.
You will have an excellent track record of research evidenced through publications. You should be highly motivated, and able to engage with scientists, clinicians and other research staff to deliver your research. A willingness to travel to overseas clinical sites to assist in sample collection is essential..