Associate Research Scientist
Bristol-Myers Squibb, Cambridge, MA, USA
Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.
Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.
The successful candidate will join the Oncology Discovery Pharmacology and In Vivo Biology group at Bristol-Myers Squibb in Cambridge, MA and aide in the advancement of early stage therapeutics in tumor immuno-biology. The position will utilize in vivo models to profile novel therapeutics targeting pathways required for tumor proliferation and survival.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the Discovery Oncology, protein engineering/antibody development, pharmaceutical optimization, and chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
- A B.S. with 2-7 years relevant industry or comparable academic experience and a clearly demonstrated skill set in in vivo oncology or cancer cell signaling is required.
- Demonstrated competency in independently using in vivo mouse tumor models to perform PK/PD and efficacy studies in conjunction with blood/tissue collection is required.
- Experience with subcutaneous syngeneic and/or xenograft tumor models is required; experience with GEMMs is a plus.
- Competency in murine dosing, i.e. PO, IP, IV, SC, is required; intra-tumor and IM is preferred.
- Proficiency in cell culture, passaging and harvesting is required. Experience with preparing adherent and suspension mammalian cells for subcutaneous and intravenous implantation preferred.
- Experience harvesting and disaggregating tumors and lymph nodes for subsequent analysis by FACS is a plus.
- Working knowledge of multi-color FACS including characterization of tumor infiltrating lymphocytes is desirable; however not required. Demonstrated interest in learning FACS is preferred.
- Experience or demonstrated interest in assessing pharmacodynamic effects in tissues using assays such as ELISAs (MSD), qPCR or WB is desirable.
- Experience with orthotopic or chemically-induced mouse models or rodent surgical experience is a plus.
- Proficiency in utilizing software such as GraphPad Prism™, electronic notebooks, Microsoft office etc. for data analysis and figure generation is required.
- Excellent organizational skills and a detail-oriented approach to the execution of experiments and record keeping is a requirement.
- Strong interpersonal skills with the ability to interact effectively with peers and management is required.
- Independently conduct mouse in vivo pharmacology experiments, including but not limited to model development, tumor implantation, dosing via IV, IP, SC, I-TUMOR, IM and PO routes, tumor measurements, health monitoring, tissue sampling by fine needle biopsy and core needle biopsy, peritoneal lavage, blood draws by retro-orbital, tail vessel micro-sampling, cardiac puncture and tissue/tumor collection at necropsy including fixation, freezing and tissue disaggregation to support ex vivo analyses.
- Independently conduct in vivo efficacy and PK/PD studies and experiments supporting the development of new pharmacology models.
- Contribute to the utilization of ELISAs (MSD), qPCR, or WB to monitor biomarkers in harvested tissues.
- Contribute to the utilization of multi-color flow cytometry to profile the immune infiltrate in harvested mouse tissues.
- Accurately maintain proper scientific documentation associated with pharmacology studies in an electronic lab notebook.
- Effectively communicate and present summaries of research results to team members or to a multidisciplinary team of researchers.
- Rotating weekend, holiday and off-hour on-site responsibilities to support BID/QD dosing, when applicable, will be expected of this position.
- This position is located in Cambridge, MA. There will be less than 10% travel.
Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.