Research Fellow

Job Details
Closing Date: 2019-05-07
Institution: University of Warwick
Term: until 31 December 2021
Keyword Names: Academic/Research
Salary: £30,395 - £39,609
Line 1: University of Warwick
City: Warwick
Country: United Kingdom

Job Description

Research Fellow

Warwick Medical School, Biomedical Cell Biology, Coventry, UK

Vacancy Overview

Applications are invited for a Postdoctoral Scientist to work on an MRC funded project entitled ‘Identifying disease promoting macrophages and tissue-identity in endometriosis’. Endometriosis is a chronic disorder that affects 176 million women world-wide. Endometriosis can cause chronic pelvic pain and infertility, there is no cure and new approaches to therapy are urgently needed. Limited treatments for the disorder exist. The Greaves lab is focused on the role of macrophages in the pathophysiology of endometriosis with the goal of identifying new therapeutic strategies to treat the disorder. The group uses a range of approaches that include examination of well-characterized human tissues, a mouse model of endometriosis (including use of genetically modified mice), and appropriate cell models.

The post holder will be based within at the Division of Biomedical Sciences, Warwick Medical School at the University of Warwick where they will work within a team led by; Dr. Erin Greaves (Principal Investigator and benefit from close association with members of teams led by other PIs at the Division of Biomedical Sciences as well as collaborators and co-applicants Prof. Philippa Saunders and Prof. Andrew Horne (EXPPECT, Edinburgh, and Dr Stephen Jenkins at the University of Edinburgh.
The position will involve travel between Gibbet Hill campus of the University and the Clinical Sciences Research Laboratory based at the University Hospital Coventry and Warwickshire site.

The primary objectives of the proposed research are to determine the ontogeny, fate and phenotype(s) of macrophages that drive the disease so as to inform our understanding of the disorder and inform the development of targeted immunotherapies. The post holder will be expected to conduct high quality research using genetically modified mice and a wide range of molecular and cellular techniques. The candidate will also be expected to participate in the collection and archiving of human tissue, which may require some flexible working.

Applications are welcome from scientists with a PhD in biological sciences who hold a current UK Home Office personal license with surgery module with experience in disease modelling in rodents. Experience in techniques such as flow cytometry and bioinformatics and a background in immunology or reproductive biology would be an advantage. The post holder will be expected to have excellent communication skills, to assist in supervision of junior staff and students and to collate and present findings at meetings and conferences as well as in the form of manuscripts.

The post is a fixed-term, full-time position. The post is available from 13th May 2019 and tenable for 3 years.

Job Description

  • To contribute to a programme of high quality research investigating ‘Disease promoting macrophages and tissue-identity in endometriosis’

Duties and responsibilities

Main Responsibilities

  • To undertake research exploring the origin and phenotype of endometriosis associated macrophages including the use of animal models, tissue collection, histological analysis including advanced imaging methods (confocal immunohistochemistry and in vivo optical imaging), flow cytometry, FACs, library prep, bioinformatics analysis (for single cell RNA-Seq), digital spatial profiling, processing and statistical analysis of data
  • Maintain accurate and up-to-date records. Present data at group meetings, section meetings, and meetings within the Institute. Regular reporting of progress to the group leader and other members of the research team
  • Participation in human tissue collection and archiving
  • Dissemination of results both orally at laboratory and other local meetings as well as by preparing text and figures for manuscripts and by giving presentations at national and international meetings
  • To continually update knowledge and understanding in the field of reproductive health and disease and to collaborate with other scientists working on inflammatory disorders
  • To provide day to day supervision and support to undergraduate and postgraduate students. To train staff and students in a range of molecular, cellular and in vivo methods as required
  • To participate in public engagement activities, postdoctoral networking and to attend seminars and research talks within University of Warwick

Planning and Organising

  • The post-holder will plan and manage their own research activity on a day to day basis, to ensure that the research is conducted in accordance with the research timetable. They will assist more junior members of the research team in planning and scheduling of their workload, in accordance with the demands of the overall project.

Problem Solving

The post holder is expected to resolve most problems relating to their own research activity with only the most serious non-standard issues reported to the line manager for assistance. They are expected to identify new areas of research relating to the pathophysiology of endometriosis, and to develop new research methods. Use initiative to analyse and interpret research data, and draw conclusions from it. Use initiative to help other researchers in the team to resolve project problems and develop new techniques and methods, as appropriate.

Decision Making

  • Taken independently: Organise own workload according to priority and adapt as necessary, setting of short-term time-lines, design experimental set-up to address specific research aims
  • In collaboration with others: Problem solving and data interpretation, experimental design and discussion of potential new research strategies